Are angiotensin receptor blockers worth their cancer risk?

Submitted by RobbinaM on Tue, 07/27/2010 - 04:43

Angiotensin receptor blockers are a type of drug used to treat high blood pressure and diabetic nephropathy. Angiotensin receptor blockers, though, may increase the risk of cancer in patients taking drugs such as Cozaar, Telmisartan, Lisinopril, Hyzaar, and Diovan. According to this study, angiotensin receptor blockers increase the probability of cancer by about one percent. In other words, patients might be a lot more likely to get cancer, but they are not a lot more likely to die from it.

Article Resource: Angiotensin receptor blockers - Cancer risk worth the benefit

The angiotensin receptor blockers study

The study, published this morning online within the Lancet Oncology journal, analyzed the medical records of 61,590 patients taking angiotensin receptor blockers. The researchers used eight “seed” studies with seven different drugs to analyze for their research. All eight trials were published before November 2009. This analysis study found that anyone taking angiotensin receptor blockers had about one percent higher chance of getting cancer. In the context of this study, "significant" means statistically significant - only about one percent. Even though the patients taking angiotensin receptor blockers were one percent more likely to get a new cancer, they were not any more likely to die from those cancers.

on-label uses of angiotensin receptor blockers

Angiotensin receptor blockers, or ARB drugs, are used to treat a wide variety of heart conditions. The angiotensin receptor blocker drug helps relax the muscles around blood vessels, keeping them from contracting. Increasingly, angiotensin receptor blockers are being used in a preventative fashion to help prevent kidney failure and heart attacks. Just 3 of the seven available angiotensin receptor blockers had sales of over $ 9 billion in 2009. Dr. Steven Nissen, a cardiologist at the Cleveland Clinic, wrote in his commentary also published in the Lancet that:

"These drugs are often overprescribed, as a result of aggressive marketing and in theabsence of evidence that they are better than angiotensin-converting enzyme (ACE) inhibitors," another class of drugs.

Take angiotensin receptor blockers?

If you do take angiotensin receptor blockers, you need to talk with your doctor about it. The increase in cancer risk from angiotensin receptor blockers does exist. The conditions angiotensin receptor blockers treat are often much more dangerous than the one percent risk of cancer.

Read More:

CBSNews.com

TheLancet.com

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